Efficient resolution of racemic crown-shaped cyclotriveratrylene derivatives and isolation and characterization of the intermediate saddle isomer

• Sven Götz,
• Andreas Schneider and
• Arne Lützen

Beilstein J. Org. Chem. 2019, 15, 1339–1346, doi:10.3762/bjoc.15.133

• ][28]. Due to our interest in dissymmetric [29][30][31][32][33][34][35][36] and concave molecular building blocks [37] and their implementation in supramolecular architectures like (allosteric) receptors [38][39][40][41][42][43][44] or metallosupramolecular helicates and cages [45][46][47][48][49][50

Towards allosteric receptors – synthesis of β-cyclodextrin-functionalised 2,2’-bipyridines and their metal complexes

• Christopher Kremer,
• Gregor Schnakenburg and
• Arne Lützen

Beilstein J. Org. Chem. 2014, 10, 814–824, doi:10.3762/bjoc.10.77

• bringing together or separating the cyclodextrin moieties from each other. Keywords: allosteric receptors; 2,2’-bipyridines; β-cyclodextrin; supramolecular chemistry; metal complexes; Introduction In biological systems, recognition events play a major role to guarantee the selectivity of essential

• ]. Depending on the substitution pattern for the central 2,2’-bipyridines, three conceptually different types of allosteric receptors can be obtained: 4,4’- or 6,6’-substitution, both leading to positive allosteric receptors, meaning that they adopt an open anti-conformation in the free state where the two

• for our allosteric receptors [20][21][22]. Hence, we also started with these here. Unfortunately, silver(I) ions turned out to be not effective in this case. Although, they seem to form complexes with compounds 1–3, we did not observe any of the characteristic shifts of the signals assigned to the

Size selective recognition of small esters by a negative allosteric hemicarcerand

• Holger Staats and
• Arne Lützen

Beilstein J. Org. Chem. 2010, 6, No. 10, doi:10.3762/bjoc.6.10

• resorcinarene moieties in different directions so that they cannot act cooperatively in the binding of the substrate. Keywords: allosteric receptors; 2,2′-bipyridine; hemicarcerand; molecular recognition; resorcin[4]arene; Introduction Nature uses allosteric effects in a very elegant manner to control

• example for a negative allosteric hemicarcerand we are now working on the improvement of the performance of our allosteric receptors, e.g. by using other cavitand-building blocks with deeper cavities. Experimental Compound 2 and its complex [(CO)3Re(2)Cl] were prepared according to our recently published